After reuniting at the end of season one, Hank (DAVID DUCHOVNY) and Karen (NATASCHA McELHONE) decide to pack up and head to New York. As part of the reconciliation, Hank undergoes a grueling vasectomy at Karen’s request. That night Hank and Karen meet Charlie (EVAN HANDLER) and Marcy (PAMELA ADLON) for drinks. They wind up bumping into Sonja (PAULA MARSHALL), the vomiting Scientologist from Season One, who’s now pregnant, and her new boyfriend Julian (ANGUS MACFADYEN), a renowned self-help guru. The group heads to a party at the home of record producer Lew Ashby (CALLUM KEITH RENNIE), where Hank has an accident when he confuses a partygoer for Karen. On the ride home, Hank gets arrested for driving under the influence and assaulting an officer.

Hank (DAVID DUCHOVNY) finds himself in jail after assaulting a mouthy police officer. Karen (NATASCHA McELHONE), still upset at Hank for his accident at the party, refuses to bail him out. In prison, Hank is reintroduced to fellow inmate Lew Ashby (CALLUM KEITH RENNIE), who proposes that Hank write Ashby’s long-awaited biography. When Hank refuses, Ashby bails them both out and tells Hank a story of the girl he loved and lost. Meanwhile, Charlie (EVAN HANDLER) gets fired after his former assistant, Dani (RACHEL MINER), plays the agency president a montage of Charlie’s self-pleasuring office sessions.

On Hank’s (DAVID DUCHOVNY) first day as biographer to Lew Ashby (CALLUM KEITH RENNIE), he’s re-introduced to Trixie (JUDY GREER), the hooker with a heart of gold, who stirs up trouble by claiming that Hank is better in bed than Ashby. When Karen (NATASCHA McELHONE) and Sonja (PAULA MARSHALL) meet to discuss a renovation project, Julian (ANGUS MACFADYEN) interrupts to work his guru magic on Karen. Becca (MADELEINE MARTIN) grudgingly starts her first day at Mia’s (MADELINE ZIMA) private school, where she meets an unexpected friend, Damien (EZRA MILLER). Meanwhile, Charlie (EVAN HANDLER) spots one of Marcy’s clients, a porn actress named Daisy (CARLA GALLO). While pitching himself as her agent, Charlie hops a ride with Daisy only to realize that he’s in the middle of an impromptu porn shoot.

Hank (DAVID DUCHOVNY) and Karen (NATASHA McELHONE) throw a dinner party for a few close friends: Charlie (EVAN HANDLER) and Marcy (PAMELA ADLON), show up high, Ashby (CALLUM KEITH RENNIE), Sonja (PAULA MARSHALL), Julian (ANGUS MACFADYEN) and Mia (MADELINE ZIMA). Becca (MADELEINE MARTIN) and her new boyfriend Damien (EZRA MILLER) round out the group. Before everyone arrives, Hank pops the question, but Karen begs off to think it over. At dinner, it’s revealed that Hank is the likely father of Sonja’s baby. Becca stands up to Julian, much to Hank’s delight. And Ashby nearly dies of an allergic reaction to sushi. At the end of the evening, Karen decides that she cannot marry Hank.

After getting dumped by Karen (NATASHA McELHONE), Hank (DAVID DUCHOVNY) is relegated to living at Ashby’s (CALLUM KEITH RENNIE) mansion. In order to distract Hank from his heartbreak, Ashby arranges a sex session with popular, yet incredibly annoying, celebrity chef, Chloe Metz (MEREDITH MONROE). Meanwhile, Charlie (EVAN HANDLER) takes on a new client, Daisy (CARLA GALLO), who’s eager to land the lead in a porn film called Vaginatown. Charlie meets with the film’s director Ronny Praeger (HAL OZSAN) and secures her the part, but only after investing $100,000 of his own savings.

Hank (DAVID DUCHOVNY) decides to seek out Lew Ashby’s (CALLUM KEITH RENNIE) long lost love. He finds her in the surprising form of Beverly Hills mom Janie Jones (MADCHEN AMICK). Later, Hank accidentally walks in on Julian (ANGUS MACFADYEN) going at it with a rocker chick he’s “mentoring.” When Hank confronts Sonja (PAULA MARSHALL) about the discovery she reveals that, much to her frustration, they have an open relationship. Mia (MADELINE ZIMA) spends the day trailed by Rolling Stone reporter Annika Staley (CARLY POPE). After finagling their way over to Ashby Manor, Hank takes a liking to Staley, but is shocked to discover Mia leaving Ashby’s bedroom later that night. Meanwhile, when a location falls through, the Runkle residence is transformed into the set of Vaginatown. The lead actor’s failings force Charlie (EVAN HANDLER) is to step in for the money shot

Hank (DAVID DUCHOVNY) and Karen (NATASHA McELHONE) attend a parentteacher conference at Becca’s (MADELEINE MARTIN) high school. Hank hits it off with the English teacher, Mrs. Patterson (JUSTINE BATEMAN), only to discover that this latest possible conquest is also the mother of Becca’s boyfriend Damien (EZRA MILLER). Meanwhile, Charlie (EVAN HANDLER) and Marcy (PAMELA ADLON) take a frightened Daisy (CARLA GALLO) into their home. When Daisy’s former manager (COLIN MALONE) shows up for reparations, Marcy is forced to reveal that she’s spent their cash stash on cocaine, forcing Charlie to hand over the keys to his prized convertible.

Hank (DAVID DUCHOVNY) spends the day at the home of Janie Jones (MADCHEN AMICK) trying to get the back story on her relationship with Lew Ashby (CALLUM KEITH RENNIE). When Janie’s husband comes home early, Hank is forced to bide his time in the pool house with the Jones family maid, Rosario (PAOLA TURBAY). When Karen (NATASCHA McELHONE) learns that Mia (MADELINE ZIMA) is having an affair with Ashby, she races to his house to confront him but winds up having a tender heart-to-heart with the legendary producer instead. Meanwhile, Charlie (EVAN HANDLER) sends Marcy (PAMELA ADLON) to her mother’s house to detox and succumbs to temptation with Daisy (CARLA GALLO).

Hank (DAVID DUCHOVNY) meets Janie Jones (MADCHEN AMICK) for a date at a Venice art gallery, where they bump into a very pregnant Sonja (PAULA MARSHALL) and Julian (ANGUS MACFADYEN). After a quick escape, Janie invites Hank back to her place, but he declines. Karen (NATASCHA McELHONE) goes on an impromptu date, of sorts, with Lew Ashby (CALLUM KEITH RENNIE). She returns home to find Hank waiting with the big news that he did not sleep with another woman. And, after a congratulatory roll in the sack, Karen finds a disturbing lump on Hank’s groin. Meanwhile, with Marcy (PAMELA ADLON) in rehab, Charlie (EVAN HANDLER) is left to hold down the fort at her waxing salon. And he and Daisy (CARLO GALLO) bond over Dirty Dancing.

While Hank (DAVID DUCHOVNY) nervously awaits the results of his biopsy, he reflects on his relationship with Karen (NATASCHA McELHONE), and we flashback to the beginning of their stormy union – an event that coincides with the tragic overdose of a famous grunge rocker. Meanwhile, Daisy (CARLA GALLO) tells Charlie (EVAN HANDLER) that she’s moving out, but Charlie doesn’t want to let her go.

To celebrate the release of Mia’s (MADELINE ZIMA) book, Ashby (CALLUM KEITH RENNIE) hosts a soiree at the manor. At the party, Karen (NATASCHA McELHONE) reveals to Hank that she hasn’t read Mia’s book. Back from rehab, Marcy (PAMELA ADLON) tries to avoid the powdered temptation all around her. Becca (MADELINE MARTIN) is devastated when she discovers Damien (EZRA MILLER) making out with another girl. And, after spotting Daisy (CARLA GALLO) with Ronny Praeger (HAL OZSAN), Charlie (EVAN HANDLER) tells Marcy he wants a divorce. Later, just as the madness is winding down, Janie Jones (MADCHEN AMICK) arrives. As Ashby tries to work up the courage to go downstairs to see her, he does a line of some very bad coke.

Hank (DAVID DUCHOVNY) completes his biography of Lew Ashby (CALLUM KEITH RENNIE). Mia (MADELINE ZIMA) departs L.A. for her cross-country book tour. Sonja (PAULA MARSHALL) gives birth to a baby who is decidedly not Hank’s. Fortunately, Julian (ANGUS MACFADYEN) steps up to the plate. Charlie (EVAN HANDLER) is reduced to working at a BMW dealership in the valley. After Daisy (CARLA GALLO) reveals that she slept with another guy, Charlie expresses his regret to an unsympathetic Marcy (PAMELA ADLON). Karen (NATASCHA McELHONE) decides to take a job in New York City – the family can finally relocate back home. Hank and a heartsick Becca (MADELEINE MARTIN) are thrilled. But when Becca and Damien (EZRA MILLER) patch things up and she decides she wants to remain in LA, Hank decides to stay behind for his daughter.