Peter and Brian’s friendship becomes strained after Brian begins dating Meg’s high school teacher. Peter finds a replacement in new best friend James Woods, who is visiting Quahog because of a suggestion to rename James Woods High School after Martin Luther King Jr.

When Peter and the guys decide to go fishing, they end up caught in a storm. Stranded on a desert island, their families fear the worst. Rescued by a cruise ship months later, Peter suprises Lois at home, where he finds out that she has a new husband.

When Chris is supposed to be hazed for a school tradition, he runs off to South America; Peter quickly becomes frustrated by his new job at the beer factory.

After a "wardrobe malfunction" occurs during a live broadcast, the FCC begins to censor all of Peter’s favorite television shows. As a result Peter creates his own TV station “PTV” which broadcasts from of the Griffin home. Peter and Brian create their own edgy programming for the station until the FCC shows up to shut down PTV, and censor all controversial material in Quahog.

After writing a story for a local magazine, Brian gets a job at The New Yorker. He admitted that he didn't graduate from college and lost his job. So he went back to college. In the end, he failed.

Lois thinks Stewie is trying to kill her due to his lack of quality time with his father, so she orders Peter to spend more time with Stewie. Meanwhile Chris starts a friendship with Herbert.

Lois discovers she has a brother named Patrick and therefore takes the family cross-country to meet him. However, it turns out that he's in a mental institution, but Lois thinks he's sane, so she checks him out to live with the Griffins. Meanwhile, Peter starts a Society for the Acceptance of Fat Men. However, the fat men of Quahog are strangled one-by-one.so the Fat Society live in terror. Who is the strangler?

When Peter’s dad visits the family, he tries to impose his religious beliefs on the family. But after a mixup with holy-water leaves Stewie in a bubble, Peter decides to form a church around his hero, The Fonz.

After Brian has a near-death experience in the hospital, he decides to lead a new life. He ends up getting a nightly singing gig with Frank Sinatra Jr., but his new lifestyle doesn't last very long. Meanwhile, Meg, after joining a new after-school group, pretends to be a lesbian.

At his high school reunion, Peter tries to impress his fellow classmates. When Peter, heading for the bathroom, charges through the crowd of people, he impresses quarterback Tom Brady, who offers Peter a spot on the New England Patriots. Meanwhile, Brian owes Stewie money, after Stewie becomes a sports bookie.

When Peter wins a maid for a week as a prize on a game show, Quagmire gains an interest in her, and they eventually marry. Quagmire, stricken with his bachelor ways, tries to get out of the marriage. Meanwhile, Lois stops breast-feeding Stewie, who, as a result, goes through withdrawals.

Peter gets a vasectomy and loses all his sex drive. Lois begins to gain weight, and as a result, Peter's regains his interest in his wife. When Lois' habits get out of control, she has a heart attack. The surgeon must remove Lois' fat to reach her heart, returning her to her normal weight. Meanwhile, Stewie's half-brother Bertram returns to confront him, where they have a war for control over the playground.

Meg becomes an intern for Mayor West. Brian, who is sure that the mayor is corrupt, tries to out him. Brian and Stewie, while undercover, discover that Meg is more than just an intern. Meanwhile, Peter and Lois go back to their folk singing days at a local talent show. When they begin using drugs, Chris stages an intervention.

After reading an erotic novel, Peter gets the idea to write one himself. Carter gets sued for publishing Peter's book on tape and loses all his money, where he is forced to become a middle-class citizen. Meanwhile, Stewie tries to train for the Olympics.

Brian's gay cousin Jasper visits the Griffin house and announces that he is engaged to his partner and wants to be married at their house. When Mayor West bans gay marriage in an effort to cover up and bring attention away from a scandal of his own, Brian resorts to hostile actions to try to change the Mayor's mind. Lois and Peter question their view towards gay marriage while Chris joins the "Young Republicans" Club to impress a girl.

Peter wants to top Joe, who just built a new home theater system, so he starts to build a multiplex in his backyard. In doing so, he discovers an Indian burial ground. He finds an Indian chief's skull and the Griffin house becomes haunted. Stewie gets sucked into the television and strange events follow as they try to get Stewie back from the poltergeist.

After robbers enter into the Griffin house, the family tries to gain safety in Peter's panic room. Trapped with no way out, Peter decides to tell his family the history of their ancestry by narrating a chain of events that describe his family's past.

After losing at a swim competition, Stewie tries to eliminate his rival by blowing up a lifeguard tower. His plan backfires though, and Stewie has a near death experience that seems to change him.

Stewie convinces Brian to go on a road trip with him to San Francisco to search for a man Stewie believes is his real father.

Stewie finds out that his life in the future is miserable. So he decides to go back in time and change events for the better.