Grace Hanadarko (Holly Hunter), a tormented, fast-living Oklahoma City police detective who, despite being at the top of her field, takes self-destruction to new lows. After seeing tremendous tragedy in her life, both professionally and personally, Grace lives life hard and fast. She drinks too much, sleeps with the wrong men and defies authority. It all catches up with her one night when, as she’s driving too fast after too many drinks, she hits a man who is walking along the road.

In an uncharacteristic moment, Grace asks for help, and she gets it – in the form an unconventional angel named Earl (Leon Rippy). Earl tells Grace that she is in trouble and running out of chances, but he wants to help lead her back to the right path. The journey for both of them will not be an easy one. For Grace, it will bring up life's most complicated issues.
Each episode of Saving Grace revolves around a specific case that the detectives are trying to solve, while delving deeper into the characters' personal lives. Kenneth Johnson (The Shield), Bailey Chase (Las Vegas), Bokeem Woodbine (The Big Hit) and Laura San Giacomo (Just Shoot Me) co-star.