When Ron and Peter cannot find enough money in the cushions to pay the rent, they have to do the unthinkable. Go back to their jobs as human guinea pigs. Testing experimental products, pills and much, much worse. This time they are given the suppository to end all suppositories and in the days to come Peter starts to think he might just have a miracle up his butt.

A radical new procedure gives Peter and Ron a chance to walk a mile in size nine pumps. Seeing life from a woman's perspective sends them on a journey of sexual awakening and self discovery, proving you can put lipstick on two pigs.

The newest Testico experiment makes the boys forget about all their problems. Too bad it makes them forget everything else as well: like how they know each other or even who they are. When he finds out about their problem, a seemingly sympathetic Nugget is more than happy to help them remember who they are. Especially when he can help them 'remember' a life they never had.

When Peter and Ron are sent home with a super intelligent, military grade vacuum to test, they are laughing. It seems like the easiest gig they have ever had until they find themselves having to outwit a homicidal home appliance. Even they do not like their odds.

Ron and Peter test the world’s strongest glue and they become closer than they ever thought possible. But will being this close drive two best friends apart?

Ron and Peter test an experimental new pheromone spray that makes them irresistible to women. The results are more effective than they expected and more horrifying than they ever imagined.

It isn’t until Ron and Peter face their deaths that they realize they’ve never really lived. Now they have to find a way to seize one last day before it’s too late.

Ron and Peter test chastity belts and have to go without sex for a week. No problem: except now that they’re not looking for sex, it has a way of finding them.

Peter takes a potent new muscle relaxant and is left totally paralyzed. Now he can only communicate through blinks while he tries to do the impossible - survive in Ron's care.

A new shampoo leaves Ron and Peter blind, and Nugget sees the perfect opportunity to live rent free. After all, the boys won't mind having a roommate - especially if they don't know he's there.

Ron and Peter lose the ability to feel pain and the doctors warn them to be careful. But that's lame, so instead Ron becomes an fear free daredevil and Pete ends up as a dominatrix’s S & M boy toy.

Testico won't tell Ron and Pete what this week's test does, and the boys get paranoid. They start to imagine symptoms everywhere. Soon they're not eating, sleeping or leaving the apartment as they quickly descend into madness.

Ron and Peter test the most dangerous thing they have ever tested: Truth Serum. Can their friendship survive this much honesty, or will they be torn apart by the secret of Peter's mysterious past?